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Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA

Hepatitis A virus (HAV) is an hepatotropic human picornavirus that is associated only with acute infection. Its pathogenesis is not well understood because there are few studies in animal models using modern methodologies. We characterized HAV infections in three chimpanzees, quantifying viral RNA b...

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Detalhes bibliográficos
Main Authors: Lanford, Robert E., Feng, Zongdi, Chavez, Deborah, Guerra, Bernadette, Brasky, Kathleen M., Zhou, Yan, Yamane, Daisuke, Perelson, Alan S., Walker, Christopher M., Lemon, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131353/
https://ncbi.nlm.nih.gov/pubmed/21690403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101939108
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