Lysophosphatidylcholines activate G2A inducing G(α)(i-1)-/G(α)(q)(/)(11)-Ca(2+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TRALI (transfusion-related acute lung injury) and directly affect the physiology of neutrophils [PMNs (polymorphonuclear leucocytes)]. Because the G2A rece...

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Autores principales: KHAN, Samina Y., MCLAUGHLIN, Nathan J. D., KELHER, Marguerite R., ECKELS, Phillip, GAMBONI-ROBERTSON, Fabia, BANERJEE, Anirban, SILLIMAN, Christopher C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131183/
https://ncbi.nlm.nih.gov/pubmed/20799926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091087
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