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PEG with Observable Shedding

A novel FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off from nanoparticles (NPs). When the NPs were targeted to cancer cell lines, the reducing redox of the endosomal compartment caused disulfide bond cleavage and shedding of the PEG layer. The fluoresc...

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Autors principals: Gao, Weiwei, Langer, Robert, Farokhzad, Omid C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131112/
https://ncbi.nlm.nih.gov/pubmed/20677297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201001868
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