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Recognition of the F&H motif by the Lowe Syndrome protein OCRL

Lowe syndrome and Type 2 Dent disease are caused by defects in the inositol 5-phosphatase OCRL. Most missense mutations in the OCRL ASH-RhoGAP domain found in affected patients abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short F&...

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Bibliografiske detaljer
Main Authors: Pirruccello, Michelle, Swan, Laura E., Folta-Stogniew, Ewa, De Camilli, Pietro
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130824/
https://ncbi.nlm.nih.gov/pubmed/21666675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2071
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