Pyruvate Kinase M2 is a PHD3-stimulated Coactivator for Hypoxia-Inducible Factor 1

The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes to tumorigenesis by mechanisms that are not explained by its known biochemical activity. We show that PKM2 gene transcription...

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Detalhes bibliográficos
Main Authors: Luo, Weibo, Hu, Hongxia, Chang, Ryan, Zhong, Jun, Knabel, Matthew, O’Meally, Robert, Cole, Robert N., Pandey, Akhilesh, Semenza, Gregg L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130564/
https://ncbi.nlm.nih.gov/pubmed/21620138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.054
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