Pyruvate Kinase M2 is a PHD3-stimulated Coactivator for Hypoxia-Inducible Factor 1

The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes to tumorigenesis by mechanisms that are not explained by its known biochemical activity. We show that PKM2 gene transcription...

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Detaylı Bibliyografya
Asıl Yazarlar: Luo, Weibo, Hu, Hongxia, Chang, Ryan, Zhong, Jun, Knabel, Matthew, O’Meally, Robert, Cole, Robert N., Pandey, Akhilesh, Semenza, Gregg L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130564/
https://ncbi.nlm.nih.gov/pubmed/21620138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.054
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