Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine

In mammalian genomes a sixth base, 5-hydroxymethylcytosine ((hm)C), is generated by enzymatic oxidation of 5-methylcytosine ((m)C). This discovery has raised fundamental questions about the functional relevance of (hm)C in mammalian genomes. Due to their very similar chemical structure, discriminati...

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Main Authors: Szwagierczak, Aleksandra, Brachmann, Andreas, Schmidt, Christine S., Bultmann, Sebastian, Leonhardt, Heinrich, Spada, Fabio
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130283/
https://ncbi.nlm.nih.gov/pubmed/21378122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr118
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