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Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA

The DNA of patients taking immunosuppressive and anti-inflammatory thiopurines contains 6-thioguanine (6-TG) and their skin is hypersensitive to ultraviolet A (UVA) radiation. DNA 6-TG absorbs UVA and generates reactive oxygen species that damage DNA and proteins. Here, we show that the DNA damage i...

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Sonraí Bibleagrafaíochta
Main Authors: Gueranger, Quentin, Kia, Azadeh, Frith, David, Karran, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130278/
https://ncbi.nlm.nih.gov/pubmed/21398635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr112
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