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Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA
The DNA of patients taking immunosuppressive and anti-inflammatory thiopurines contains 6-thioguanine (6-TG) and their skin is hypersensitive to ultraviolet A (UVA) radiation. DNA 6-TG absorbs UVA and generates reactive oxygen species that damage DNA and proteins. Here, we show that the DNA damage i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130278/ https://ncbi.nlm.nih.gov/pubmed/21398635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr112 |
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