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Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation
Canonical Wnt-signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance, however its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. Yet, β-catenin has additional roles at the...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130149/ https://ncbi.nlm.nih.gov/pubmed/21685890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2260 |
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