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c-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway
A-Raf kinase can inhibit apoptosis by binding to the pro-apoptotic MST2 kinase. This function relies on expression of hnRNP H, which ensures the correct splicing of a-raf mRNA needed to produce full-length A-Raf protein. Here we show that expression of hnRNP H and production of full-length A-Raf is...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130132/ https://ncbi.nlm.nih.gov/pubmed/21512137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4447 |
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