Role of the primary motor cortex in L-DOPA-induced dyskinesia and its modulation by 5-HT1A receptor stimulation

While serotonin 5-HT1A receptor (5-HT1AR) agonists reduce L-DOPA-induced dyskinesias (LID) by normalizing activity in the basal ganglia neurocircuitry, recent evidence suggests putative 5-HT1AR within the primary motor cortex (M1) may also contribute. To better characterize this possible mechanism,...

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Autors principals: Ostock, Corinne Y, Dupre, Kristin B, Jaunarajs, Karen L Eskow, Walters, Hannah, George, Jessica, Krolewski, David, Walker, Paul D, Bishop, Christopher
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130088/
https://ncbi.nlm.nih.gov/pubmed/21635907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.05.021
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