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Destabilization and denaturation of cellular protein by glutathione depletion
This investigation tested the hypothesis that depletion of intracellular glutathione, in contrast to its oxidation, could lead to non-native oxidation of protein thiols, thereby trapping proteins in an unstable conformation. Chinese hamster cells were exposed to the α,β-unsaturated dicarboxylic acid...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cell Stress Society International
1997
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312997/ https://ncbi.nlm.nih.gov/pubmed/9314607 |
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