Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from all causes. The molecular mechanisms driving HSC differentiation are not fully understood. Because macroscopic...

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Bibliographische Detailangaben
Hauptverfasser: Olsen, Abby L., Bloomer, Steven A., Chan, Erick P., Gaça, Marianna D. A., Georges, Penelope C., Sackey, Bridget, Uemura, Masayuki, Janmey, Paul A., Wells, Rebecca G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2011
Schlagworte:
Liver and Biliary Tract
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129929/
https://ncbi.nlm.nih.gov/pubmed/21527725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00412.2010
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