Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from all causes. The molecular mechanisms driving HSC differentiation are not fully understood. Because macroscopic...

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Autores principales: Olsen, Abby L., Bloomer, Steven A., Chan, Erick P., Gaça, Marianna D. A., Georges, Penelope C., Sackey, Bridget, Uemura, Masayuki, Janmey, Paul A., Wells, Rebecca G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2011
Materias:
Liver and Biliary Tract
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129929/
https://ncbi.nlm.nih.gov/pubmed/21527725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00412.2010
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