Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from all causes. The molecular mechanisms driving HSC differentiation are not fully understood. Because macroscopic...

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Detalhes bibliográficos
Main Authors: Olsen, Abby L., Bloomer, Steven A., Chan, Erick P., Gaça, Marianna D. A., Georges, Penelope C., Sackey, Bridget, Uemura, Masayuki, Janmey, Paul A., Wells, Rebecca G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129929/
https://ncbi.nlm.nih.gov/pubmed/21527725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00412.2010
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