Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from all causes. The molecular mechanisms driving HSC differentiation are not fully understood. Because macroscopic...

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Main Authors: Olsen, Abby L., Bloomer, Steven A., Chan, Erick P., Gaça, Marianna D. A., Georges, Penelope C., Sackey, Bridget, Uemura, Masayuki, Janmey, Paul A., Wells, Rebecca G.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2011
Assuntos:
Liver and Biliary Tract
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129929/
https://ncbi.nlm.nih.gov/pubmed/21527725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00412.2010
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