Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

Storage of excess calories as triglycerides is central to obesity and its associated disorders. Glycerol-3-phosphate acyltransferases (GPATs) catalyze the initial step in acylglyceride syntheses, including triglyceride synthesis. We utilized a novel small-molecule GPAT inhibitor, FSG67, to investiga...

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Detalhes bibliográficos
Main Authors: Kuhajda, Francis P., Aja, Susan, Tu, Yajun, Han, Wan Fang, Medghalchi, Susan M., El Meskini, Rajaa, Landree, Leslie E., Peterson, Jonathan M., Daniels, Khadija, Wong, Kody, Wydysh, Edward A., Townsend, Craig A., Ronnett, Gabriele V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129873/
https://ncbi.nlm.nih.gov/pubmed/21490364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00147.2011
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