Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy

JX-594 is a targeted and granulocyte-macrophage colony stimulating factor (GM-CSF) expressing oncolytic poxvirus designed to selectively replicate in and destroy cancer cells through viral oncolysis and tumor-specific immunity. In a phase 1 trial, JX-594 injection into hepatocellular carcinoma (HCC)...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Heo, Jeong, Breitbach, Caroline J, Moon, Anne, Kim, Chang Won, Patt, Rick, Kim, Mi Kyung, Lee, Yu Kyung, Oh, Sung Yong, Woo, Hyun Young, Parato, Kelley, Rintoul, Julia, Falls, Theresa, Hickman, Theresa, Rhee, Byung-Geon, Bell, John C, Kirn, David H, Hwang, Tae-Ho
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2011
Θέματα:
Original Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129795/
https://ncbi.nlm.nih.gov/pubmed/21427706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.39
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