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Reduced thermotolerance in aged cells results from a loss of an hsp72- mediated control of JNK signaling pathway

Aged organisms exhibit a greatly decreased ability to induce the major heat shock protein, Hsp72, in response to stresses, a phenomenon that can also be observed in cell cultures (Heydari AR, Takahashi R, Gutsmann A, You S and Richardson A (1994) Hsp70 and aging. Experientia 50: 1092–1098). Hsp72 wa...

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Bibliografiske detaljer
Main Authors: Volloch, Vladimir, Mosser, Dick D., Massie, Bernard, Sherman, Michael Y.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Stress Society International 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC312972/
https://ncbi.nlm.nih.gov/pubmed/9880239
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