Generation of a Kupffer Cell-evading Adenovirus for Systemic and Liver-directed Gene Transfer

As much as 90% of an intravenously (i.v.) injected dose of adenovirus serotype 5 (Ad5) is absorbed and destroyed by liver Kupffer cells. Viruses that escape these cells can then transduce hepatocytes after binding factor X (FX). Given that interactions with FX and Kupffer cells are thought to occur...

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Detalhes bibliográficos
Main Authors: Khare, Reeti, May, Shannon M, Vetrini, Francesco, Weaver, Eric A, Palmer, Donna, Rosewell, Amanda, Grove, Nathan, Ng, Philip, Barry, Michael A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129569/
https://ncbi.nlm.nih.gov/pubmed/21505422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.71
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