Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer

Hepatic gene transfer using adeno-associated viral (AAV) vectors has been shown to efficiently induce immunological tolerance to a variety of proteins. Regulatory T-cells (Treg) induced by this route suppress humoral and cellular immune responses against the transgene product. In this study, we exam...

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Autors principals: Hoffman, Brad E, Martino, Ashley T, Sack, Brandon K, Cao, Ou, Liao, Gongxian, Terhorst, Cox, Herzog, Roland W
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129563/
https://ncbi.nlm.nih.gov/pubmed/21386826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.33
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