Protein Kinase A Effects of an Expressed PRKAR1A Mutation Associated with Aggressive Tumors

Most PRKAR1A tumorigenic mutations lead to nonsense mRNA that is decayed; tumor formation has been associated with an increase in type II protein kinase A (PKA) subunits. The IVS6+1G>T PRKAR1A mutation leads to a protein lacking exon 6 sequences [R1αΔ184-236 (R1αΔ6)]. We compared in vitro R1αΔ6 w...

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Detalhes bibliográficos
Main Authors: Meoli, Elise, Bossis, Ioannis, Cazabat, Laure, Mavrakis, Manos, Horvath, Anelia, Stergiopoulos, Sotiris, Shiferaw, Miriam L., Fumey, Glawdys, Perlemoine, Karine, Muchow, Michael, Robinson-White, Audrey, Weinberg, Frank, Nesterova, Maria, Patronas, Yianna, Groussin, Lionel, Bertherat, Jérôme, Stratakis, Constantine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129544/
https://ncbi.nlm.nih.gov/pubmed/18451138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0064
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