Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination

Neuregulin-1 (Nrg1) is encoded by a single gene and exists in naturally secreted and transmembrane isoforms. Nrg1 exerts its signaling activity through interaction with its cognate ErbB receptors. Multiple membrane-anchored Nrg1 isoforms, present in six different membrane topologies, must be process...

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Autors principals: Luo, Xiaoyang, Prior, Marguerite, He, Wanxia, Hu, Xiangyou, Tang, Xiaoying, Shen, Weizhen, Yadav, Satya, Kiryu-Seo, Sumiko, Miller, Robert, Trapp, Bruce D., Yan, Riqiang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129178/
https://ncbi.nlm.nih.gov/pubmed/21576249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.251538
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