Molecular Basis for the Reduced Catalytic Activity of the Naturally Occurring T560M Mutant of Human 12/15-Lipoxygenase That Has Been Implicated in Coronary Artery Disease

Lipoxygenases have been implicated in cardiovascular disease. A rare single-nucleotide polymorphism causing T560M exchange has recently been described, and this mutation leads to a near null variant of the enzyme encoded for by the ALOX15 gene. When we inspected the three-dimensional structure of th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Schurmann, Kathrin, Anton, Monika, Ivanov, Igor, Richter, Constanze, Kuhn, Hartmut, Walther, Matthias
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Enzymology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129173/
https://ncbi.nlm.nih.gov/pubmed/21558275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211821
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