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Assembly of the Human Origin Recognition Complex Occurs through Independent Nuclear Localization of Its Components
Initiation of eukaryotic genome duplication begins when a six-subunit origin recognition complex (ORC) binds to DNA. However, the mechanism by which this occurs in vivo and the roles played by individual subunits appear to differ significantly among organisms. Previous studies identified a soluble h...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129165/ https://ncbi.nlm.nih.gov/pubmed/21555516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215988 |
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