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Assembly of the Human Origin Recognition Complex Occurs through Independent Nuclear Localization of Its Components

Initiation of eukaryotic genome duplication begins when a six-subunit origin recognition complex (ORC) binds to DNA. However, the mechanism by which this occurs in vivo and the roles played by individual subunits appear to differ significantly among organisms. Previous studies identified a soluble h...

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Detalhes bibliográficos
Main Authors: Ghosh, Soma, Vassilev, Alex P., Zhang, Junmei, Zhao, Yingming, DePamphilis, Melvin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129165/
https://ncbi.nlm.nih.gov/pubmed/21555516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215988
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