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Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis

Previous studies have suggested that the activity of the mammalian origin recognition complex (ORC) is regulated by cell-cycle-dependent changes in its Orc1 subunit. Here, we show that Orc1 modifications such as mono-ubiquitylation and hyperphosphorylation that occur normally during S and G2-M phase...

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Detalhes bibliográficos
Main Authors: Saha, Tapas, Ghosh, Soma, Vassilev, Alex, DePamphilis, Melvin L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766536/
https://ncbi.nlm.nih.gov/pubmed/16537645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.02851
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