Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

Toll-like receptors (TLRs) are pattern-recognition receptors that recognize microbial ligands and subsequently trigger intracellular signaling pathways involving transcription factors such as NFκB and MAPKs such as p38. TLR signaling can regulate both transcriptional and post-transcriptional events...

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Detalhes bibliográficos
Main Authors: Flannery, Sinead M., Keating, Sinead E., Szymak, Joanna, Bowie, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129149/
https://ncbi.nlm.nih.gov/pubmed/21606490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248351
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