Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases

Benzoquinoid ansamycins, such as herbimycin A (HA) and geldanamycin (GA), are antibiotics that exhibit anti-tumor effects. These compounds have been shown to result in the intracellular depletion of important growth signaling molecules. Recently, GA has been shown to bind tightly to Hsp90, thereby i...

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Pubblicato in:	Cell Stress Chaperones
Autori principali:	Sakagami, Masayuki, Morrison, Peter, Welch, William J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 1999
Soggetti:	Original Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312914/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10467105/
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