Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels

Berberine is a plant alkaloid with multiple pharmacological actions, including antidiarrhoeal activity and has been shown to inhibit Cl(−) secretion in distal colon. The aims of this study were to determine the molecular signaling mechanisms of action of berberine on Cl(−) secretion and the ion tran...

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Detalhes bibliográficos
Main Authors: Alzamora, Rodrigo, O’Mahony, Fiona, Ko, Wing-Hung, Yip, Tiffany Wai-Nga, Carter, Derek, Irnaten, Mustapha, Harvey, Brian Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129074/
https://ncbi.nlm.nih.gov/pubmed/21747769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2011.00033
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