Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and bioc...

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Bibliografiska uppgifter
Huvudupphovsmän: Makarov, Vadim, Manina, Giulia, Mikusova, Katarina, Möllmann, Ute, Ryabova, Olga, Saint-Joanis, Brigitte, Dhar, Neeraj, Pasca, Maria Rosalia, Buroni, Silvia, Lucarelli, Anna Paola, Milano, Anna, De Rossi, Edda, Belanova, Martina, Bobovska, Adela, Dianiskova, Petronela, Kordulakova, Jana, Sala, Claudia, Fullam, Elizabeth, Schneider, Patricia, McKinney, John D., Brodin, Priscille, Christophe, Thierry, Waddell, Simon, Butcher, Philip, Albrethsen, Jakob, Rosenkrands, Ida, Brosch, Roland, Nandi, Vrinda, Bharath, Sowmya, Gaonkar, Sheshagiri, Shandil, Radha K., Balasubramanian, Venkataraman, Balganesh, Tanjore, Tyagi, Sandeep, Grosset, Jacques, Riccardi, Giovanna, Cole, Stewart T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128490/
https://ncbi.nlm.nih.gov/pubmed/19299584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171583
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