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PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

The Wnt-responsive transcription factor LEF1 can activate transcription in association with β-catenin and repress transcription in association with Groucho. In search of additional regulatory mechanisms of LEF1 function, we identified the protein inhibitor of activated STAT, PIASy, as a novel intera...

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Udgivet i:Genes Dev
Principais autores: Sachdev, Shrikesh, Bruhn, Laurakay, Sieber, Heidemarie, Pichler, Andrea, Melchior, Frauke, Grosschedl, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312834/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11731474/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.944801
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