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The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila
In the Drosophila circadian clock, the CLOCK/CYCLE complex activates the period and timeless genes that negatively feedback on CLOCK/CYCLE activity. The 24-h pace of this cycle depends on the stability of the clock proteins. RING-domain E3 ubiquitin ligases have been shown to destabilize PERIOD or T...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128276/ https://ncbi.nlm.nih.gov/pubmed/21525955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.64 |
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