The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila

In the Drosophila circadian clock, the CLOCK/CYCLE complex activates the period and timeless genes that negatively feedback on CLOCK/CYCLE activity. The 24-h pace of this cycle depends on the stability of the clock proteins. RING-domain E3 ubiquitin ligases have been shown to destabilize PERIOD or T...

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Main Authors: Lamaze, Angélique, Lamouroux, Annie, Vias, Carine, Hung, Hsiu-Cheng, Weber, Frank, Rouyer, François
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128276/
https://ncbi.nlm.nih.gov/pubmed/21525955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.64
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