Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

Gene inactivation of the orphan G protein-coupled receptor LGR4, a paralogue of the epithelial-stem-cell marker LGR5, results in a 50% decrease in epithelial cell proliferation and an 80% reduction in terminal differentiation of Paneth cells in postnatal mouse intestinal crypts. When cultured ex viv...

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Detalhes bibliográficos
Main Authors: Mustata, Roxana C, Van Loy, Tom, Lefort, Anne, Libert, Frédérick, Strollo, Sandra, Vassart, Gilbert, Garcia, Marie-Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128273/
https://ncbi.nlm.nih.gov/pubmed/21508962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.52
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