Immune Activation Mediated Change in Alpha-1-Acid Glycoprotein: Impact on Total and Free Lopinavir Plasma Exposure

BACKGROUND: Immune mediated changes in circulating α-1-acid glycoprotein (AAG), a type 1 acute phase protein, which binds protease inhibitors (PI), may alter protein binding and contribute to PI's pharmacokinetic (PK) variability. METHODS: In a prospective, 2-phase intensive PK study on antiret...

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Autori principali: Ofotokun, Ighovwerha, Lennox, Jeffrey L., Eaton, Molly E., Ritchie, James C., Easley, Kirk A., Masalovich, Svetlana E., Long, Mary C., Acosta, Edward P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128238/
https://ncbi.nlm.nih.gov/pubmed/21209245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270010385118
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