Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

Breakdown or absence of vascular oxygen delivery is a hallmark of many common human diseases, including cancer, myocardial infarction, and stroke. The chief mediator of hypoxic response in mammalian tissues is the transcription factor hypoxia-inducible factor 1 (HIF-1), and its oxygen-sensitive comp...

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Main Authors: Schipani, Ernestina, Ryan, Heather E., Didrickson, Susanna, Kobayashi, Tatsuya, Knight, Melissa, Johnson, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC312800/
https://ncbi.nlm.nih.gov/pubmed/11691837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.934301
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