Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation?

BACKGROUND: Heparan sulfate (HS) is present on the surface of virtually all mammalian cells and is a major component of the extracellular matrix (ECM), where it plays a pivotal role in cell-cell and cell-matrix cross-talk through its large interactome. Disruption of HS biosynthesis in mice results i...

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Autori principali: Thompson, Sophie M, Connell, Marilyn G, van Kuppevelt, Toin H, Xu, Ruoyan, Turnbull, Jeremy E, Losty, Paul D, Fernig, David G, Jesudason, Edwin C
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127989/
https://ncbi.nlm.nih.gov/pubmed/21672206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-11-38
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