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Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production
B-lymphocyte development is dictated by the protein products of functionally rearranged Ig heavy (H) and light (L) chain genes. Ig rearrangement begins in pro-B cells at the IgH locus. If pro-B cells generate a productive allele, they assemble a pre-B cell receptor complex, which signals their diffe...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127927/ https://ncbi.nlm.nih.gov/pubmed/21670279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019224108 |
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