Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production

B-lymphocyte development is dictated by the protein products of functionally rearranged Ig heavy (H) and light (L) chain genes. Ig rearrangement begins in pro-B cells at the IgH locus. If pro-B cells generate a productive allele, they assemble a pre-B cell receptor complex, which signals their diffe...

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Detalhes bibliográficos
Main Authors: Lutz, Johannes, Heideman, Marinus R., Roth, Edith, van den Berk, Paul, Müller, Werner, Raman, Chander, Wabl, Matthias, Jacobs, Heinz, Jäck, Hans-Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127927/
https://ncbi.nlm.nih.gov/pubmed/21670279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019224108
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