Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in fa...

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Autors principals: Lawson, William E., Cheng, Dong-Sheng, Degryse, Amber L., Tanjore, Harikrishna, Polosukhin, Vasiliy V., Xu, Xiaochuan C., Newcomb, Dawn C., Jones, Brittany R., Roldan, Juan, Lane, Kirk B., Morrisey, Edward E., Beers, Michael F., Yull, Fiona E., Blackwell, Timothy S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127925/
https://ncbi.nlm.nih.gov/pubmed/21670280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107559108
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