Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemia

We have used conditional gene ablation to uncover a dramatic and unpredicted role for the winged-helix transcription factor Foxa2 (formerly HNF-3β) in pancreatic β-cell differentiation and metabolism. Mice that lack Foxa2 specifically in β cells (Foxa2(loxP/loxP); Ins.Cre mice) are severely hypoglyc...

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Библиографические подробности
Главные авторы: Sund, Newman J., Vatamaniuk, Marko Z., Casey, Melissa, Ang, Siew-Lan, Magnuson, Mark A., Stoffers, Doris A., Matschinsky, Franz M., Kaestner, Klaus H.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2001
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC312732/
https://ncbi.nlm.nih.gov/pubmed/11445544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.901601
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