Role of Isovaleryl-CoA Dehydrogenase and Short Branched-Chain Acyl-CoA Dehydrogenase in the Metabolism of Valproic Acid: Implications for the Branched-Chain Amino Acid Oxidation Pathway

Many biological systems including the oxidative catabolic pathway for branched-chain amino acids (BCAAs) are affected in vivo by valproate therapy. In this study, we investigated the potential effect of valproic acid (VPA) and some of its metabolites on the metabolism of BCAAs. In vitro studies were...

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Main Authors: Luís, Paula B. M., Ruiter, Jos P. N., IJlst, Lodewijk, Tavares de Almeida, Isabel, Duran, Marinus, Mohsen, Al-Walid, Vockley, Jerry, Wanders, Ronald J. A., Silva, Margarida F. B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127238/
https://ncbi.nlm.nih.gov/pubmed/21430231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.037606
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