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Inviability of a DNA2 deletion mutant is due to the DNA damage checkpoint
Dna2 is a dual polarity exo/endonuclease, and 5′ to 3′ DNA helicase involved in Okazaki Fragment Processing (OFP) and Double-Strand Break (DSB) Repair. In yeast, DNA2 is an essential gene, as expected for a DNA replication protein. Suppression of the lethality of dna2Δ mutants has been found to occu...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127164/ https://ncbi.nlm.nih.gov/pubmed/21508669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.10.15643 |
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