Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

The budding yeast transcriptional activator Gcn4 is rapidly degraded in an SCF(Cdc4)-dependent manner in vivo. Upon fractionation of yeast extracts to identify factors that mediate Gcn4 ubiquitination, we found that Srb10 phosphorylates Gcn4 and thereby marks it for recognition by SCF(Cdc4) ubiquiti...

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Publicado en:	Genes Dev
Autores principales:	Chi, Yong, Huddleston, Michael J., Zhang, Xiaolong, Young, Richard A., Annan, Roland S., Carr, Steven A., Deshaies, Raymond J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 2001
Materias:	Research Paper
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312682/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.867501
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