Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

The budding yeast transcriptional activator Gcn4 is rapidly degraded in an SCF(Cdc4)-dependent manner in vivo. Upon fractionation of yeast extracts to identify factors that mediate Gcn4 ubiquitination, we found that Srb10 phosphorylates Gcn4 and thereby marks it for recognition by SCF(Cdc4) ubiquiti...

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में प्रकाशित:	Genes Dev
मुख्य लेखकों:	Chi, Yong, Huddleston, Michael J., Zhang, Xiaolong, Young, Richard A., Annan, Roland S., Carr, Steven A., Deshaies, Raymond J.
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Cold Spring Harbor Laboratory Press 2001
विषय:	Research Paper
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312682/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.867501
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