Rescue of Photoreceptor Degeneration by Curcumin in Transgenic Rats with P23H Rhodopsin Mutation

The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP). There are no effective therapies to treat this condition. Compounds that enhance diss...

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Main Authors: Vasireddy, Vidyullatha, Chavali, Venkata R. M., Joseph, Victory T., Kadam, Rajendra, Lin, Jonathan H., Jamison, Jeffrey A., Kompella, Uday B., Reddy, Geereddy Bhanuprakash, Ayyagari, Radha
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126808/
https://ncbi.nlm.nih.gov/pubmed/21738619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021193
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