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Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sites

Abasic (AP) sites are one of the most frequently formed lesions in DNA, and they present a strong block to continued synthesis by the replicative DNA machinery. Here we show efficient bypass of an AP site by the combined action of yeast DNA polymerases δ and ζ. In this reaction, Polδ inserts an A nu...

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Published in:Genes Dev
Main Authors: Haracska, Lajos, Unk, Ildiko, Johnson, Robert E., Johansson, Erik, Burgers, Peter M.J., Prakash, Satya, Prakash, Louise
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2001
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Research Paper
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312678/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11316789/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.882301
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