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The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-related protein that functions as a tumor suppressor. We found that merlin mediates contact inhibition of growth through signals from the extracellular matrix. At high cell density, merlin becomes hypo-phosphorylated an...

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Udgivet i:Genes Dev
Principais autores: Morrison, Helen, Sherman, Larry S., Legg, James, Banine, Fatima, Isacke, Clare, Haipek, Carrie A., Gutmann, David H., Ponta, Helmut, Herrlich, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312675/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11316791/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.189601
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