The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
Histone deacetylation plays an important role in methylated DNA silencing. Recent studies indicated that the methyl-CpG-binding protein, MBD2, is a component of the MeCP1 histone deacetylase complex. Interestingly, MBD2 is able to recruit the nucleosome remodeling and histone deacetylase, NuRD, to m...
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| Udgivet i: | Genes Dev |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312663/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11297506/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.876201 |
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