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The E3 Ubiquitin Ligase Activity Associated with the Adenoviral E1B-55K–E4orf6 Complex Does Not Require CRM1-Dependent Export

The adenovirus type 5 (Ad5) E1B-55K and E4orf6 (E1B-55K/E4orf6) proteins are multifunctional regulators of Ad5 replication, participating in many processes required for virus growth. A complex containing the two proteins mediates the degradation of cellular proteins through assembly of an E3 ubiquit...

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Autors principals: Schmid, Melanie, Kindsmüller, Kathrin, Wimmer, Peter, Groitl, Peter, Gonzalez, Ramon A., Dobner, Thomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126608/
https://ncbi.nlm.nih.gov/pubmed/21561915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02368-10
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