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Capturing the Herpes Simplex Virus Core Fusion Complex (gB-gH/gL) in an Acidic Environment

Herpes simplex virus (HSV) entry requires the core fusion machinery of gH/gL and gB as well as gD and a gD receptor. When gD binds receptor, it undergoes conformational changes that presumably activate gH/gL, which then activates gB to carry out fusion. gB is a class III viral fusion protein, while...

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Detalhes bibliográficos
Main Authors: Cairns, Tina M., Whitbeck, J. Charles, Lou, Huan, Heldwein, Ekaterina E., Chowdary, Tirumala K., Eisenberg, Roselyn J., Cohen, Gary H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126480/
https://ncbi.nlm.nih.gov/pubmed/21507973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00119-11
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