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Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA

Unlike other eukaryotes, the protein-coding genes of Trypanosoma cruzi are arranged in large polycistronic gene clusters transcribed by polymerase II (Pol II). Thus, it is thought that trypanosomes rely solely on posttranscriptional processes to regulate gene expression. Here, we show that the gluco...

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Autors principals: Ekanayake, Dilrukshi K., Minning, Todd, Weatherly, Brent, Gunasekera, Kapila, Nilsson, Daniel, Tarleton, Rick, Ochsenreiter, Torsten, Sabatini, Robert
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126337/
https://ncbi.nlm.nih.gov/pubmed/21321080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01277-10
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